Reduction
It is a chemical reaction between molecular hydrogen (H2) and aromatic nitro compounds or element, usually in the presence of a metal catalyst such as nickel, palladium or platinum which, leads to the formation of corresponding aromatic amines or the aryl halides are reduced to aromatics. The process is commonly employed to reduce or saturate organic compounds.
Such type of reduction processes in the presence of palladium or platinum catalysts are routinely carried out at our site based on a solid infrastructure for safe handling of the material. SGRL also has gained an expertise in handling reduction processes in the presence of Ranney Nickle catalyst.
The reduction chemistry is widely used for conversion of aromatic nitro compounds with hydrogen in the presence of palladium or platinum catalysts to their corresponding aromatic amines also known as anilines. Under similar conditions, aryl halides can also be reduced to the corresponding aromatic compound in a dehalogenation reaction. Below mentioned are the reduction techniques of which Hydrogenation is widely accepted.
Hydrogenation
Hydrogenation is widely used for the conversion of unsaturated compounds to their saturated analogy. Typically, these reactions are carried out in the either in presence of a precious metal (palladium or platinum are common) or in presence of pyrophoric catalysts such as Ranney Nickle. Catalysts can be either heterogeneous (insoluble) or homogeneous (soluble) depending on the nature of the process. Catalyst selection plays an important part of the process development as the catalyst will deeply affect the reaction conditions, selectivity, and yield of the process.
SGRL has gained the expertise for the right selectivity of the catalyst and has the facility to upscale the process right from 1 Ltr to 2000 Litre with pressure handling capacity upto 60 bar pressure.
Customer Benefits:
- Safe handling of pyrophoric catalysts
- Robust infrastructure to handle high pressure operations upto 40 bar pressure
- Safe production processes with all the measures in place
Wolff-Kishner Reaction
The Wolff-Kishner reaction is used to reduce carbonyl compounds to alkanes in a direct and selective way. SGRL with it’s experience and expertise can develop a robust production processes which will be more uniform, safer and more stable, increasing both yield and quality.
Reduction using borohydride Salts
SGRL has wide experience of using various borohydride salts for reduction process and for the selection of right type of hydride salts leading to more uniform, safer and more stable, increasing both yield and quality. NaBH4 is one of the widely used boro-hydride salts to reduces many organic carbonyls. Most typically, it is used for reduction of ketones and aldehydes to alcohols. It efficiently reduces acyl chlorides, anhydrides, α-hydroxylactones, thioesters, and imines at mild conditions.